Lokke utilized BIG to produce several high-resolution animated "Reggie the Rattler" issues, his inaugural online political cartoon, later marketed as an "anti-Congress" series. He distributed these gratis, alongside other BIG artwork, to persuade system operators to pay $35 for his "art support service," granting access to "superior EGA/VGA BIG illustrations, comic strips, cartoons, and online publications."
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研究进一步验证了小胶质细胞可作为特异性干预靶点，米诺环素等药物能够实现精准调节，这为临床开发兼具镇痛、抗抑郁且不损害认知功能的新型药物提供了重要理论依据，有望改善慢性疼痛共病抑郁患者的诊疗现状。